来自百部根的抗菌二苯乙烯类化合物。
Antibacterial stilbenoids from the roots of Stemona tuberosa.
作者信息
Lin Li-Gen, Yang Xin-Zhou, Tang Chun-Ping, Ke Chang-Qiang, Zhang Ji-Bao, Ye Yang
机构信息
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu-Chong-Zhi Road, Zhangjiang Hi-tech Park, Shanghai 201203, PR China.
出版信息
Phytochemistry. 2008 Jan;69(2):457-63. doi: 10.1016/j.phytochem.2007.07.012. Epub 2007 Sep 10.
Twelve dihydrostilbenes, stilbostemins N-Y (1-12), and a phenanthraquinone, stemanthraquinone (13), were isolated and identified from roots of Stemona tuberosa, along with five known dihydrostilbenes. Their structures were established on the basis of 1D and 2D NMR and other spectroscopic analyses. Dihydrostilbene 8 exhibited strong activity against Bacillus pumilus (MIT 12.5-25 microg/mL). Many tested compounds exhibited moderate antibacterial activities.
从百部的根部分离并鉴定出12种二氢茋类化合物，即百部茋N - Y（1 - 12），以及1种菲醌类化合物，即百部蒽醌（13），同时还有5种已知的二氢茋类化合物。它们的结构通过一维和二维核磁共振及其他光谱分析得以确定。二氢茋8对短小芽孢杆菌表现出较强活性（最低抑菌浓度为12.5 - 25微克/毫升）。许多受试化合物表现出中等抗菌活性。
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