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通过基质辅助激光解吸电离质谱法对全身小鼠切片中β-肽分布进行成像。

Imaging of a beta-peptide distribution in whole-body mice sections by MALDI mass spectrometry.

作者信息

Stoeckli Markus, Staab Dieter, Schweitzer Alain, Gardiner James, Seebach Dieter

机构信息

Novartis Institutes for BioMedical Research, Basel, Switzerland.

出版信息

J Am Soc Mass Spectrom. 2007 Nov;18(11):1921-4. doi: 10.1016/j.jasms.2007.08.005. Epub 2007 Aug 16.

DOI:10.1016/j.jasms.2007.08.005
PMID:17827032
Abstract

Mass spectrometric imaging was applied to assess compound distributions on whole-body sections of mice after i.v. dosing of a beta-peptide and an alpha-peptide control. Animals were sacrificed at different time points (5 min, 1 h, 24 h) post-dose, providing simultaneous spatial as well as kinetic information. As a result of this study, no detection of the alpha-peptide control was observed at 1 h post-dose, while retention of the beta-peptide was observed for longer than 24 h post-dose.

摘要

静脉注射一种β-肽和一种α-肽对照后，应用质谱成像技术评估小鼠全身切片上化合物的分布情况。在给药后的不同时间点（5分钟、1小时、24小时）处死动物，可同时提供空间和动力学信息。这项研究的结果表明，给药后1小时未检测到α-肽对照，而β-肽在给药后24小时以上仍有留存。

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