Riesz Péter, Nyirády Péter, Szucs Miklós, Szendrôi Attila, Majoros Attila, Bánfi Gergely, Kiss András, Lotz Gábor, Törzsök Péter, Kelemen Zsolt, Romics Imre
Semmelweis Egyetem, Altalános Orvostudományi Kar, Urológiai Klinika, Budapest.
Orv Hetil. 2007 Sep 16;148(37):1751-6. doi: 10.1556/OH.2007.28120.
Malignant tumour of the penis is a rare disease. Although most of the cases are squamous cell carcinoma histologically, operation is managed by the urologist because of its location.
Experience with the treatment and attendance of penile cancer is presented by the author. Results were both retrospectively and prospectively worked up.
Between June 1996 and June 2006 there was operation performed in 50 patients. Mean age of men was 63.1 (31-83) years. Ninety-four percent of tumours were squamous cell carcinoma, 2 (4%) verrucosus carcinoma, in one case malignant melanoma. Pathological T stadium was T1 in 23 cases (46%), T2 in 19 (38%) patients, in 6 (12%) cases T3 and in 1 (2%) T4. Differentiation was grade 1 in 12 (24%), grade 2 in 27 (54%) and grade 3 in 10 (20%) cases. One side inguinal lymph node metastases were found in 11 (22%) and both side in 8 (16%) patients. In anamnesis 4 (8%) patients underwent circumcision because of phimosis, and 25 (50%) patients had had phimosis by identification of cancer. Seventeen patients (34%) were given chemotherapy after surgical treatment. Mean survival time of all patients was 31,4 (2-114) months.
Phimosis plays an important role in development of penile cancer, that's surgical treatment does not prevent the higher chance of incidence rate. The disease behaves aggressively, spreading through lymphatic vessels, where in advanced stadium, or in low differentiation cases it is already demonstrable by diagnosis. In the choice of therapy, stadium-oriented principle should be predominant. With early operation, long-term survival can be achieved.
阴茎恶性肿瘤是一种罕见疾病。尽管大多数病例在组织学上为鳞状细胞癌，但因其位置原因，手术由泌尿外科医生负责。
作者介绍了阴茎癌的治疗及诊治经验。对结果进行了回顾性和前瞻性分析。
1996年6月至2006年6月期间，对50例患者进行了手术。男性的平均年龄为63.1岁（31 - 83岁）。94%的肿瘤为鳞状细胞癌，2例（4%）为疣状癌，1例为恶性黑色素瘤。病理T分期为T1的有23例（46%），T2的有19例（38%），T3的有6例（12%），T4的有1例（2%）。分化程度为1级的有12例（24%），2级的有27例（54%），3级的有10例（20%）。11例（22%）患者发现单侧腹股沟淋巴结转移，8例（16%）患者为双侧转移。在病史中，4例（8%）患者因包茎接受过包皮环切术，25例（50%）患者在确诊癌症时存在包茎。17例患者（34%）在手术治疗后接受了化疗。所有患者的平均生存时间为31.4个月（2 - 114个月）。
包茎在阴茎癌的发生中起重要作用，手术治疗并不能降低较高的发病率。该疾病侵袭性强，通过淋巴管扩散，在晚期或低分化病例中，在诊断时即可发现。在治疗选择上，应以分期为导向的原则为主。早期手术可实现长期生存。
