Mikaeloff Yann, Caridade Guillaume, Tardieu Marc, Suissa Samy
Assistance publique-Hôpitaux de Paris, Service de Neurologie Pédiatrique, Hôpital Bicêtre, INSERM U802, Université Paris Sud 11, Le Kremlin Bicêtre, France.
Brain. 2007 Oct;130(Pt 10):2589-95. doi: 10.1093/brain/awm198. Epub 2007 Sep 7.
The possibility of a link between active smoking and incident multiple sclerosis (MS) has been raised. However, possible links between incidence of MS and passive smoking, particularly in children, have not been analysed. We conducted a population-based, case-control study. The cases were patients with incident MS occurring between 1994 and 2003, before the age of 16 years, in France. Each case was matched for age, sex and geographic origin with 12 controls, randomly selected from the French general population. Information about the smoking history of the parents of the cases and controls was collected with a standardized questionnaire. Conditional logistic regression was used to estimate the rate ratio (RR) of MS associated with parental smoking at home. The 129 cases of MS were matched with 1038 controls. Information about parental smoking was obtained for all these cases and controls. Exposure to parental smoking was noted in 62.0% of cases and 45.1% of controls. The adjusted RR of a first episode of MS associated with exposure to parental smoking at home was 2.12 (95% confidence interval: 1.43-3.15). Stratification for age showed that this increase in risk was significantly associated with the longer duration of exposure in older cases (over 10 years of age at the time of the index episode)-RR 2.49 (1.53-4.08)-than in younger cases. Children exposed to parent smoking have a higher MS risk. The duration of exposure also affects the level of risk.
主动吸烟与多发性硬化症（MS）发病之间存在关联的可能性已被提出。然而，MS发病率与被动吸烟之间的可能联系，尤其是在儿童中的联系，尚未得到分析。我们进行了一项基于人群的病例对照研究。病例为1994年至2003年间在法国16岁之前发病的MS患者。每个病例按照年龄、性别和地理来源与12名对照进行匹配，这些对照从法国普通人群中随机选取。通过标准化问卷收集病例和对照父母的吸烟史信息。使用条件逻辑回归来估计与在家中父母吸烟相关的MS发病率比（RR）。129例MS病例与1038名对照进行了匹配。获得了所有这些病例和对照的父母吸烟信息。62.0%的病例和45.1%的对照存在父母吸烟暴露情况。在家中暴露于父母吸烟与MS首发相关的调整后RR为2.12（95%置信区间：1.43 - 3.15）。按年龄分层显示，这种风险增加在年龄较大的病例（指数发作时超过10岁）中与暴露时间较长显著相关 - RR为2.49（1.53 - 4.08） - 高于年龄较小的病例。暴露于父母吸烟的儿童患MS的风险更高。暴露持续时间也会影响风险水平。
