费氏弧菌LuxR-LuxI调控子的转录组分析。
Transcriptome analysis of the Vibrio fischeri LuxR-LuxI regulon.
作者信息
Antunes Luis Caetano M, Schaefer Amy L, Ferreira Rosana B R, Qin Nan, Stevens Ann M, Ruby Edward G, Greenberg E Peter
机构信息
Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA.
出版信息
J Bacteriol. 2007 Nov;189(22):8387-91. doi: 10.1128/JB.00736-07. Epub 2007 Sep 7.
Abstract
The Vibrio fischeri quorum-sensing signal N-3-oxohexanoyl-l-homoserine lactone (3OC6-HSL) activates expression of the seven-gene luminescence operon. We used microarrays to unveil 18 additional 3OC6-HSL-controlled genes, 3 of which had been identified by other means previously. We show most of these genes are regulated by the 3OC6-HSL-responsive transcriptional regulator LuxR directly. This demonstrates that V. fischeri quorum sensing regulates a substantial number of genes other than those involved in light production.
摘要
费氏弧菌群体感应信号N-3-氧代己酰基-L-高丝氨酸内酯（3OC6-HSL）可激活七基因发光操纵子的表达。我们使用微阵列揭示了另外18个受3OC6-HSL调控的基因，其中3个基因先前已通过其他方法鉴定出来。我们发现这些基因中的大多数直接受3OC6-HSL响应转录调节因子LuxR的调控。这表明费氏弧菌群体感应调节大量基因，而非仅调节那些参与发光的基因。
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