Jones Jeffrey L, Kruszon-Moran Deanna, Sanders-Lewis Kolby, Wilson Marianna
Division of Parasitic Diseases, National Center for Zoonotic, Vectorborne, and Enteric Diseases, CCID, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Am J Trop Med Hyg. 2007 Sep;77(3):405-10.
Toxoplasma gondii can cause congenital, neurologic, ocular, and mild or asymptomatic infection. To determine the U.S. prevalence of T. gondii infection, we tested sera collected from the National Health and Nutrition Examination Survey (NHANES) 1999-2004 for T. gondii immunoglobulin G antibodies in persons 6-49 years old and contrasted the results to those comparable in NHANES III (1988-1994) (ages 12-49 years). Of the 17,672 persons examined in NHANES 1999-2004, 15,960 (90%) were tested. The age-adjusted T. gondii seroprevalence among persons 6-49 years old was 10.8% (95% confidence limits [CL] 9.6%, 11.9%), and among women 15-44 years old, 11.0% (95% CL 9.5%, 12.4%). T. gondii seroprevalence declined from 14.1% to 9.0% (P < 0.001) from NHANES III to NHANES 1999-2004 among U.S.-born persons ages 12-49 years. Although T. gondii infects many persons in the U.S., the prevalence has declined in the past decade.
刚地弓形虫可引起先天性、神经性、眼部以及轻度或无症状感染。为确定美国刚地弓形虫感染的流行情况，我们检测了1999 - 2004年国家健康和营养检查调查（NHANES）收集的6至49岁人群血清中的刚地弓形虫免疫球蛋白G抗体，并将结果与NHANES III（1988 - 1994年）（12至49岁）中的可比结果进行对比。在1999 - 2004年NHANES检查的17,672人中，15,960人（90%）接受了检测。6至49岁人群经年龄调整后的刚地弓形虫血清阳性率为10.8%（95%置信区间[CL] 9.6%，11.9%），15至44岁女性为11.0%（95% CL 9.5%，12.4%）。在美国出生的12至49岁人群中，刚地弓形虫血清阳性率从NHANES III时的14.1%降至1999 - 2004年的9.0%（P < 0.001）。虽然刚地弓形虫在美国感染了许多人，但在过去十年中流行率有所下降。
