甲硝唑生物测定法。
Metronidazole bioassay.
作者信息
Speck W T, Stein A B, Rosenkranz H S
出版信息
Antimicrob Agents Chemother. 1976 Feb;9(2):260-1. doi: 10.1128/AAC.9.2.260.
Abstract
Urine from patients receiving metronidazole [1-(2-hydroxyethyl)-2-methyl-5-nitromidazole] orally or per vagina were subjected to paper chromatographic fractionation and examined for anticlostridial activity. Unmodified metronidazole and several metabolites were detected. These findings indicate that the clostridial bioassay may be limited in its applicability to the study of the pharmacodynamics of metronidazole as it does not differentiate between the parent substance and some of its metabolites. Moreover, some of the latter, although they possess antibacterial activity, may not have antiprotozoan activity.
摘要
对口服或经阴道给予甲硝唑[1-(2-羟乙基)-2-甲基-5-硝基咪唑]的患者的尿液进行纸色谱分离，并检测其抗梭菌活性。检测到未修饰的甲硝唑和几种代谢物。这些发现表明，梭菌生物测定法在甲硝唑药效学研究中的适用性可能有限，因为它无法区分母体物质及其一些代谢物。此外，后者中的一些虽然具有抗菌活性，但可能没有抗原虫活性。
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本文引用的文献
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[The activity of 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole (R. P. 8823) against experimental Trichomonas vaginalis infections].[1-(2-羟乙基)-2-甲基-5-硝基咪唑（R.P.8823）对实验性阴道毛滴虫感染的活性]
Ann Inst Pasteur (Paris). 1959 Feb;96(2):238-41.
2
Isolation and identification of the major urinary metabolite of metronidazole.甲硝唑主要尿代谢物的分离与鉴定。
Life Sci. 1967 Sep 1;6(17):1811-9. doi: 10.1016/0024-3205(67)90209-3.
3
The isolation and identification of the urinary oxidative metabolites of metronidazole in man.人体中甲硝唑尿液氧化代谢物的分离与鉴定。
J Pharmacol Exp Ther. 1968 Jun;161(2):373-81.
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Bactericidal activity of five antimicrobial agents against Bacteroides fragilis.五种抗菌剂对脆弱拟杆菌的杀菌活性。
J Infect Dis. 1972 Jul;126(1):104-7. doi: 10.1093/infdis/126.1.104.
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Metronidazole versus anaerobes. In vitro data and initial clinical observations.甲硝唑与厌氧菌。体外数据及初步临床观察。
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