Speck W T, Stein A B, Rosenkranz H S
Antimicrob Agents Chemother. 1976 Feb;9(2):260-1. doi: 10.1128/AAC.9.2.260.
Urine from patients receiving metronidazole [1-(2-hydroxyethyl)-2-methyl-5-nitromidazole] orally or per vagina were subjected to paper chromatographic fractionation and examined for anticlostridial activity. Unmodified metronidazole and several metabolites were detected. These findings indicate that the clostridial bioassay may be limited in its applicability to the study of the pharmacodynamics of metronidazole as it does not differentiate between the parent substance and some of its metabolites. Moreover, some of the latter, although they possess antibacterial activity, may not have antiprotozoan activity.
对口服或经阴道给予甲硝唑[1-(2-羟乙基)-2-甲基-5-硝基咪唑]的患者的尿液进行纸色谱分离，并检测其抗梭菌活性。检测到未修饰的甲硝唑和几种代谢物。这些发现表明，梭菌生物测定法在甲硝唑药效学研究中的适用性可能有限，因为它无法区分母体物质及其一些代谢物。此外，后者中的一些虽然具有抗菌活性，但可能没有抗原虫活性。
