来自康氏崖豆藤的α-葡萄糖苷酶抑制剂。

Alpha-glucosidase inhibitors from Millettia conraui.

作者信息

Tiabou Tchinda Alembert, Nahar Khan Shamsun, Fuendjiep Victorine, Ngandeu François, Ngono Ngane Annie, Choudhary Muhammad Iqbal

机构信息

Center of Medicinal Plants Studies and Traditional Medicine (CRPMT), Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaaoundé, Cameroon.

出版信息

Chem Pharm Bull (Tokyo). 2007 Sep;55(9):1402-3. doi: 10.1248/cpb.55.1402.

DOI:10.1248/cpb.55.1402

PMID:17827772

Abstract

A new geranylated isoflavone, 7-O-geranyl-6-methoxypseudobaptigenin (1) was isolated from the stem barks of Millettia conraui, along with known compounds 5-methoxydurmillone (2), conrauinone A (3), beta-amyrine (4), sitosterol (5), 3-O-beta-D-glucopyranosyl sitosterol (6) and n-docosanol (7). Compounds 1 and 4 showed a significant alpha-glucosidase inhibitory activity. The structures of the compounds were determined by analysis of their spectroscopic data.

摘要

从康氏崖豆藤（Millettia conraui）的茎皮中分离出一种新的香叶基化异黄酮，7-O-香叶基-6-甲氧基拟补骨脂素（1），以及已知化合物5-甲氧基杜密酮（2）、康氏崖豆藤醌A（3）、β-香树脂醇（4）、甾醇（5）、3-O-β-D-吡喃葡萄糖基甾醇（6）和正二十二醇（7）。化合物1和4表现出显著的α-葡萄糖苷酶抑制活性。通过对其光谱数据的分析确定了这些化合物的结构。