来自 Terminalia superba 的具有免疫抑制特性的 α-葡萄糖苷酶抑制剂鞣花酸衍生物。

Alpha-glucosidase inhibitors ellagic acid derivatives with immunoinhibitory properties from Terminalia superba.

作者信息

Tabopda Turibio Kuiate, Ngoupayo Joseph, Liu Jiawei, Ali Muhammad Shaiq, Khan Shamsun Nahar, Ngadjui Bonaventure Tchaleu, Luu Bang

机构信息

Département de Chimie Organique, Université de Yaoundé I, Yaoundé, Cameroon.

出版信息

Chem Pharm Bull (Tokyo). 2008 Jun;56(6):847-50. doi: 10.1248/cpb.56.847.

DOI:10.1248/cpb.56.847

PMID:18520093

Abstract

Fractionation of stem barks of Terminalia superba yielded two new ellagic acid derivatives, 3,4'-di-O-methylellagic acid 3'-O-beta-D-xylopyranoside (1) and 4'-O-galloy-3,3'-di-O-methylellagic acid 4-O-beta-D-xylopyranoside (2) together with known 3,3'-di-O-methylellagic acid, ellagic acid and 3,3'-di-O-methylellagic acid 4'-O-beta-D-xylopyranoside. Compounds (1) and (2) showed significant alpha-glucosidase inhibition activity and possessed significant immunoinhibitory activities with no cytotoxic effects.

摘要

对 Terminalia superba 的茎皮进行分级分离得到了两种新的鞣花酸衍生物，3,4'-二 -O-甲基鞣花酸 3'-O-β-D-木糖苷（1）和 4'-O-没食子酰基 -3,3'-二 -O-甲基鞣花酸 4-O-β-D-木糖苷（2），以及已知的 3,3'-二 -O-甲基鞣花酸、鞣花酸和 3,3'-二 -O-甲基鞣花酸 4'-O-β-D-木糖苷。化合物（1）和（2）显示出显著的α-葡萄糖苷酶抑制活性，并且具有显著的免疫抑制活性，且无细胞毒性作用。