美叶崖豆藤美叶亚种鱼藤酮类化合物的抗疟活性及X射线晶体结构
Anti-plasmodial activities and X-ray crystal structures of rotenoids from Millettia usaramensis subspecies usaramensis.
作者信息
Yenesew Abiy, Derese Solomon, Midiwo Jacob O, Oketch-Rabah Hellen A, Lisgarten John, Palmer Rex, Heydenreich Matthias, Peter Martin G, Akala Hosea, Wangui Julia, Liyala Pamela, Waters Norman C
机构信息
Department of Chemistry, University of Nairobi, PO Box 30197, Nairobi, Kenya.
出版信息
Phytochemistry. 2003 Oct;64(3):773-9. doi: 10.1016/s0031-9422(03)00373-x.
The dichloromethane extract of the stem bark of Millettia usaramensis subspecies usaramensis showed anti-plasmodial activity against the chloroquine sensitive (D6) and chloroquine resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the extract led to the identification of a new rotenoid, (6aR,12aS)-2,3-methylenedioxy-9-methoxy-8-(3,3-dimethylallyl)-12a-hydroxyrotenoid (trivial name, usararotenoid C) along with known flavonoids (usararotenoid A, 12a-epimillettosin, 6a,12a-dehydromillettone, barbigerone and 4'-O-geranylisoliquiritigenin) as the anti-plasmodial principles. The structures were determined by spectroscopic analyses. CD and X-ray analyses established absolute configurations.
乌桑崖豆藤亚种乌桑崖豆藤茎皮的二氯甲烷提取物对恶性疟原虫的氯喹敏感株（D6）和氯喹耐药株（W2）显示出抗疟活性。对该提取物进行色谱分离，鉴定出一种新的鱼藤酮类化合物，（6aR，12aS）-2,3-亚甲二氧基-9-甲氧基-8-（3,3-二甲基烯丙基）-12a-羟基鱼藤酮类化合物（俗名，乌桑鱼藤酮C），以及已知的黄酮类化合物（乌桑鱼藤酮A、12a-表米列托辛、6a，12a-脱氢米列酮、巴比吉酮和4'-O-香叶基异甘草素）作为抗疟成分。通过光谱分析确定了其结构。圆二色光谱（CD）和X射线分析确定了绝对构型。
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