Lin Jou-Wei, Dai Dao-Fu, Chou Yi-Hua, Huang Li-Ying, Hwang Juey-Jen
Cardiovascular Center, National Taiwan University Hospital, Yun-Lin Branch.
Int Heart J. 2007 Jul;48(4):463-75. doi: 10.1536/ihj.48.463.
This study was designed to illustrate the effects of C-reactive protein (CRP) and interleukin polymorphisms on serum CRP levels.
A total of 390 patients with coronary heart disease (CHD) were recruited and high-sensitivity CRP levels were measured. Six polymorphic alleles on the genes of CRP, IL-1, and the IL-1 receptor antagonist were identified. A classification tree was applied to determine their effects and interactions on serum CRP levels.
In the hypertensive CHD patients, the presence of CRP + 1059 GC heterozygotes was associated with a lower risk for elevated CRP levels (OR = 0.318, P = 0.001). The coexistence of CRP + 1059 GC and IL-1beta-511 (CT or TT) might result in reduction in the CRP levels compared to IL-1beta-511 CC (OR = 0.222, P = 0.088 and OR = 0.148, P = 0.060, respectively).
The results demonstrated the distribution of CRP-related polymorphisms and the interactions in Taiwanese patients with CHD.
本研究旨在阐明C反应蛋白（CRP）和白细胞介素基因多态性对血清CRP水平的影响。
共招募390例冠心病（CHD）患者并检测其高敏CRP水平。鉴定了CRP、IL-1及IL-1受体拮抗剂基因上的6个多态性等位基因。应用分类树确定它们对血清CRP水平的影响及相互作用。
在高血压冠心病患者中，CRP +1059 GC杂合子的存在与CRP水平升高风险较低相关（OR = 0.318，P = 0.001）。与IL-1β -511 CC相比，CRP +1059 GC与IL-1β -511（CT或TT）共存可能导致CRP水平降低（OR分别为0.222，P = 0.088和OR = 0.148，P = 0.060）。
结果表明了台湾冠心病患者中CRP相关多态性的分布及相互作用。
