Liu Juan, Meng Shu, Ding Yi, Wu Ya-fei
Department of Periodontology, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2010 Jun;45(6):331-6.
To investigate the relationship between C-reactive protein (CRP) + 1444C/T, CRP+1059G/C polymorphisms and chronic periodontitis (CP) in a Han Chinese population.
Clinical periodontal parameters [attachment loss (AL) probing depth (PD) and bleeding on probing (BOP)], and serum CRP levels were examined in CP patients (n = 126) and healthy subjects (n = 113).
The mean serum CRP level [(1.74 ± 1.67) mg/L] was significantly higher in the CP group than in the control group [(0.57 ± 0.39) mg/L], P < 0.001. In the control group, serum CRP levels were significantly lower in subjects with the CRP +1059 GC and CC genotypes than those with the CRP +1059 GG genotype (P < 0.01). There was no significant difference between genotypes in the CP group. In CP and the control groups, serum CRP levels were significantly higher in subjects with the CRP + 1444 CT and TT genotypes compared to those with the CRP + 1444 CC genotype (P < 0.5). The percentage of CRP + 1059 C allele was 6.7% (17/252) in the CP group and 4.9% (11/226) in the control group. The percentage of CRP + 1444 T allele was 6.3% (16/252) in the CP group and 5.3% (12/226) in the control group (P > 0.5). There was no significant difference between groups in both allele frequencies (P > 0.5). The association of CRP + 1059G/C, CRP + 1444 C/T polymorphisms with CP was not found in a regression model (P > 0.5).
The presence of a CRP + 1059C-allele was associated with lower serum CRP levels and the presence of a CRP + 1444T-allele was associated with higher serum CRP levels. However, the data suggested that CRP + 1059G/C, CRP + 1444 C/T polymorphisms were not significantly associated with serum CRP levels of chronic periodontitis patients in ethnic Han Chinese.
探讨汉族人群中C反应蛋白（CRP）+1444C/T、CRP+1059G/C基因多态性与慢性牙周炎（CP）的关系。
检测CP患者（n=126）和健康受试者（n=113）的临床牙周参数[附着丧失（AL）、探诊深度（PD）和探诊出血（BOP）]以及血清CRP水平。
CP组血清CRP平均水平[（1.74±1.67）mg/L]显著高于对照组[（0.57±0.39）mg/L]，P<0.001。在对照组中，CRP+1059 GC和CC基因型受试者的血清CRP水平显著低于CRP+1059 GG基因型受试者（P<0.01）。CP组各基因型之间无显著差异。在CP组和对照组中，CRP+1444 CT和TT基因型受试者的血清CRP水平显著高于CRP+1444 CC基因型受试者（P<0.5）。CP组中CRP+1059 C等位基因的百分比为6.7%（17/252），对照组为4.9%（11/226）。CP组中CRP+1444 T等位基因的百分比为6.3%（16/252），对照组为5.3%（12/226）（P>0.5）。两组等位基因频率均无显著差异（P>0.5）。回归模型未发现CRP+1059G/C、CRP+1444 C/T基因多态性与CP有关联（P>0.5）。
CRP+1059C等位基因的存在与较低的血清CRP水平相关，CRP+1444T等位基因的存在与较高的血清CRP水平相关。然而，数据表明CRP+1059G/C、CRP+1444 C/T基因多态性与汉族慢性牙周炎患者的血清CRP水平无显著关联。
