Comparato Giuseppe, Fanigliulo Libera, Aragona Giovanni, Cavestro Giulia M, Cavallaro Lucas G, Leandro Gioacchino, Pilotto Alberto, Nervi Giorgio, Soliani Paolo, Sianesi Mario, Franzé Angelo, Di Mario Francesco
University of Parma, Parma, Italy.
Dig Dis. 2007;25(3):252-9. doi: 10.1159/000103896.
Quality of life (QoL) is becoming a major issue in the evaluation of any therapeutic intervention.
To assess the QoL in patients with uncomplicated symptomatic diverticular disease (DD) and to elucidate the influence of two different treatments either on symptoms or QoL.
58 outpatients affected by uncomplicated symptomatic DD, admitted in our Gastroenterological Unit from October 2003 to March 2004, were enrolled. Patients were randomly assigned to two different treatments consisting of rifaximin or mesalazine for 10 days every month for a period of 6 months. QoL was evaluated by means of an SF-36 questionnaire and clinical evaluation was registered by means of a global symptomatic score (GSS) at baseline and after 6 months.
At baseline, lower values in all SF-36 domains were confirmed in patients with DD. Both rifaximin and mesalazine groups showed a significant reduction of their mean GSS (p < 0.01 and p < 0.001, respectively) and improvement of SF-36 mean scores after therapy, even though treatment with mesalazine showed better results.
DD has a negative impact on QoL. Cyclic treatment with poorly absorbable antibiotics or anti-inflammatory drugs relieves symptoms and improves QoL.
生活质量（QoL）正成为评估任何治疗干预措施的一个主要问题。
评估单纯症状性憩室病（DD）患者的生活质量，并阐明两种不同治疗方法对症状或生活质量的影响。
纳入了2003年10月至2004年3月期间在我们胃肠病科住院的58例单纯症状性DD门诊患者。患者被随机分配到两种不同的治疗组，分别接受利福昔明或美沙拉嗪治疗，每月治疗10天，为期6个月。通过SF - 36问卷评估生活质量，并在基线和6个月后通过整体症状评分（GSS）进行临床评估。
在基线时，DD患者在所有SF - 36领域的得分均较低。利福昔明组和美沙拉嗪组的平均GSS均显著降低（分别为p < 0.01和p < 0.001），且治疗后SF - 36平均得分均有所改善，尽管美沙拉嗪治疗效果更佳。
DD对生活质量有负面影响。使用吸收性差的抗生素或抗炎药物进行周期性治疗可缓解症状并改善生活质量。
