Gastroenterology Service, ASL BAT, Andria (BT), Italy.
Neurogastroenterol Motil. 2012 Sep;24(9):836-e396. doi: 10.1111/j.1365-2982.2012.01946.x. Epub 2012 Jun 11.
Inflammation may be detected in diverticular disease (DD), and fibrosis may also develop. We assessed the mucosal expression of bFGF, SD1, and TNF-α in DD according to the severity of the disease. Moreover, we assessed the response to therapy of these cytokines in acute uncomplicated diverticulitis (AUD).
Fifteen patients affected by AUD and seven patients affected by symptomatic uncomplicated diverticular disease (SUDD) were enrolled. Patients with asymptomatic diverticulosis (AD), segmental colitis associated with diverticulosis (SCAD), ulcerative colitis (UC), and healthy subjects (HC) served as control groups.
The expression of bFGF, SD1, and TNF-α was significantly higher in diverticulitis than in healthy controls, in diverticulosis, and in uncomplicated diverticular disease. Cytokines were significantly higher in uncomplicated diverticular disease than in healthy controls. Cytokine expression in diverticulitis did not differ significantly from that of ulcerative colitis. After treatment, TNF-α expression dropped significantly.
CONCLUSIONS & INFERENCES: Mucosal TNF-α is overexpressed only in symptomatic DD, while SD1 and bFGF are already overexpressed in AD. Finally, TNF-α but not SD1 or bFGF expression seems to be influenced by the treatment in AUD.
炎症可能在憩室疾病（DD）中被检测到，纤维化也可能发展。我们根据疾病的严重程度评估了 DD 中 bFGF、SD1 和 TNF-α 的黏膜表达。此外，我们评估了这些细胞因子在急性单纯性憩室炎（AUD）中的治疗反应。
纳入了 15 例 AUD 患者和 7 例有症状单纯性憩室疾病（SUDD）患者。无症状憩室病（AD）、伴有憩室病的节段性结肠炎（SCAD）、溃疡性结肠炎（UC）和健康受试者（HC）作为对照组。
与健康对照组、憩室病和单纯性憩室疾病相比，憩室炎中 bFGF、SD1 和 TNF-α 的表达显著升高。在单纯性憩室疾病中细胞因子显著高于健康对照组。憩室炎中细胞因子的表达与溃疡性结肠炎无显著差异。治疗后，TNF-α的表达显著下降。
只有在有症状的 DD 中，黏膜 TNF-α才过度表达，而 SD1 和 bFGF 在 AD 中已经过度表达。最后，似乎只有 TNF-α，而不是 SD1 或 bFGF 的表达受 AUD 治疗的影响。
