Pine C M, Curnow M M T, Burnside G, Nicholson J A, Roberts A J
WHO Collaborating Centre in Community Oral Health, School of Dental Sciences, University of Liverpool, Liverpool, UK.
Caries Res. 2007;41(6):431-6. doi: 10.1159/000104800. Epub 2007 Sep 7.
This study measured dental caries in children after cessation of a 30-month randomised clinical trial in which the intervention group received supervised toothbrushing once a day at school with 1,000 ppm fluoride toothpaste and a home support package encouraging twice-daily toothbrushing. The non-intervention group did not brush at school or receive the home support package. Children were aged 5 years at baseline and were examined every 6 months during the trial, then at 6, 18, 30 and 54 months after the end of the trial. Significantly less caries developed in first permanent molars of intervention children at the end of the trial. Of the 428 children who were examined at the end of the trial 329 (77%) were examined 54 months later when the children were aged 12 years on average. The intervention group still had less caries (D3FS caries increment 1.62) than the non-intervention children (D3FS caries increment 2.65, p < 0.05). Prolonged benefits have been found for intervention children principally in less caries in first permanent molars. Further follow-up at an age when the second molars and premolars have all erupted will help determine whether this benefit is due to a long-term behavioural change or a prolonged biological effect.
本研究在一项为期30个月的随机临床试验结束后，对儿童龋齿情况进行了测量。在该试验中，干预组在学校每天接受一次使用含1000 ppm氟化物牙膏的监督刷牙，并收到一份鼓励每日刷牙两次的家庭支持包。非干预组不在学校刷牙，也未收到家庭支持包。儿童在基线时为5岁，在试验期间每6个月接受一次检查，然后在试验结束后的6个月、18个月、30个月和54个月接受检查。在试验结束时，干预组儿童的第一恒磨牙中龋齿的发展明显较少。在试验结束时接受检查的428名儿童中，有329名（77%）在54个月后再次接受检查，此时儿童平均年龄为12岁。干预组的龋齿仍然比非干预组儿童少（D3FS龋齿增量为1.62）（非干预组D3FS龋齿增量为2.65，p<0.05）。已发现干预组儿童有长期益处，主要表现为第一恒磨牙龋齿较少。在第二磨牙和前磨牙全部萌出的年龄进行进一步随访，将有助于确定这种益处是由于长期行为改变还是长期生物学效应。
