两亲性树枝状多肽作为具有抗菌特性的非顺序药效团模型。
Amphiphilic dendrimeric peptides as model non-sequential pharmacophores with antimicrobial properties.
作者信息
Janiszewska Jolanta, Urbanczyk-Lipkowska Zofia
机构信息
Industrial Chemistry Research Institute, Polish Academy of Sciences, Warsaw, Poland.
出版信息
J Mol Microbiol Biotechnol. 2007;13(4):220-5. doi: 10.1159/000104751.
PMID:17827972
Abstract
A concept of application of dendrimer chemistry for construction of 'non-sequential pharmacophore', mimicking active conformation of linear antimicrobial peptides, is introduced. It resulted in the synthesis of a family of low- molecular-weight basic peptide dendrimers with antimicrobial properties against Staphylococcus aureus (Gram-positive), Escherichia coli (Gram-negative) and Candida albicans.
摘要
引入了一种利用树枝状大分子化学构建“非顺序药效团”的概念，该药效团可模拟线性抗菌肽的活性构象。这导致合成了一系列具有抗金黄色葡萄球菌（革兰氏阳性）、大肠杆菌（革兰氏阴性）和白色念珠菌抗菌特性的低分子量碱性肽树枝状大分子。
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