Midura-Nowaczek Krystyna, Markowska Agnieszka
Department of Organic Chemistry, Medical University of Bialystok, Bialystok, Poland.
Perspect Medicin Chem. 2014 Oct 12;6:73-80. doi: 10.4137/PMC.S13215. eCollection 2014.
Antimicrobial peptides (AMPs) are an essential part of innate immunity. These compounds have been considered as potential therapeutics because of their broad-spectrum activities and proven ability to avoid antimicrobial resistance, but their clinical and commercial developments have some limitations, such as susceptibility to proteases and a high cost of peptide production. To overcome these problems, many researchers have tried to develop short active peptides, their modifications and mimics with better properties while retaining their basic features of natural AMPs such as cationic charge and the amphipathic structure.
抗菌肽（AMPs）是固有免疫的重要组成部分。由于这些化合物具有广谱活性且已证实能够避免产生抗药性，因此被视为潜在的治疗药物，但其临床和商业开发存在一些局限性，例如易受蛋白酶影响以及肽生产成本高昂。为克服这些问题，许多研究人员试图开发具有更好特性的短活性肽、其修饰物和模拟物，同时保留天然抗菌肽的基本特征，如阳离子电荷和两亲性结构。
