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[茶对大鼠体内NMBz A形成及食管肿瘤形成的预防作用]

[Prevention of in vivo formation of NMBz A and the formation of oesophageal tumour by tea in rats].

作者信息

Xu Y, Han C

机构信息

Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing.

出版信息

Zhonghua Yu Fang Yi Xue Za Zhi. 1991 Jul;25(4):201-4.

PMID:1782821
Abstract

Five groups of rats (22 per group) were intubated with precursors of N-Nitrosomethylbenzylamine (NMBzA), i.e. methylbenzylamine (1 mmol/kg) and sodium nitrite (0.5 mmol/kg), and five varieties of Chinese tea. One positive control group was intubated with precursors of NM2A without tea and one negative control group with tap water and sodium nitrite. After 12 week's treatment, significantly less lesions and papillomas in esophageal mucosa, examined by naked eye or by microscope, were found in the tea-treated groups than in the non-tea-treated positive control group. The results confirmed the anti-tumour ability of Chinese tea by blocking the in vivo formation of NMBzA in rats.

摘要

将五组大鼠(每组22只)用N-亚硝基甲基苄胺(NMBzA)的前体物质即甲基苄胺(1毫摩尔/千克)和亚硝酸钠(0.5毫摩尔/千克)以及五种中国茶进行插管处理。一个阳性对照组用不含茶的NM2A前体物质进行插管处理,一个阴性对照组用自来水和亚硝酸钠进行插管处理。经过12周的处理后,与未用茶处理的阳性对照组相比,通过肉眼或显微镜检查发现,用茶处理的组食管黏膜中的病变和乳头状瘤明显更少。结果证实了中国茶通过阻断大鼠体内NMBzA的形成具有抗肿瘤能力。

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