Xu Y, Chi H
Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing.
Biomed Environ Sci. 1990 Dec;3(4):406-12.
Five groups of rats (22 per group) were intubated with precursors of N-nitrosomethylbenzylamine (NMBzA), i.e., methylbenzylamine (1 mmol/kg body wt) and sodium nitrite (0.5 mmol/kg body wt), and with five different varieties of Chinese tea twice a week. One positive control group was intubated with precursors of NMBzA without tea, and a negative control group was given tap water and sodium nitrite only. After 12 weeks of treatment, significantly fewer lesions and papillomas in the esophageal mucosa were found in the tea-treated group than in the positive control group. The results confirmed the anticarcinogenic effects of Chinese tea in rats by blocking the in vivo formation of NMBzA.
将五组大鼠（每组22只）用N-亚硝基甲基苄胺（NMBzA）的前体物质进行插管，即甲基苄胺（1 mmol/kg体重）和亚硝酸钠（0.5 mmol/kg体重），并每周两次用五种不同品种的中国茶进行插管。一个阳性对照组用NMBzA的前体物质进行插管但不饮茶，一个阴性对照组仅给予自来水和亚硝酸钠。治疗12周后，发现饮茶组食管黏膜中的病变和乳头状瘤明显少于阳性对照组。结果证实了中国茶通过阻断NMBzA的体内形成对大鼠具有抗癌作用。
