Izaki Yoshinori, Akema Tatsuo
Department of Physiology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan.
Exp Brain Res. 2008 Jan;184(2):249-53. doi: 10.1007/s00221-007-1098-6. Epub 2007 Sep 8.
Previously, we reported an elevation in the power of the medial prefrontal cortex (PFC) local field potential spontaneous gamma-band (40-100 Hz) after long-term depression (LTD) but not long-term potentiation (LTP) in the rat ventral hippocampus CA1 (vCA1)-PFC pathway. In the present study, we analyzed the PFC local field potential before and after the induction of posterior dorsal hippocampus CA1 (pdCA1)-PFC LTP/LTD in vivo. In contrast with vCA1-PFC, the present study found that gamma-band power elevation was associated with pdCA1-PFC LTP but not LTD, although we observed a correlation between LTD and the gamma-band power change. The differences between vCA1- and pdCA1-PFC pathways might be related to differences in synaptic plasticity and behavioral functions. Since the neural connection of the hippocampus and PFC is believed to be involved in the function of the working memory, sustained gamma-band power elevation in the PFC might be related to this function.
此前，我们报道了在大鼠腹侧海马CA1（vCA1）-内侧前额叶皮质（PFC）通路中，长期抑郁（LTD）而非长期增强（LTP）后，内侧前额叶皮质局部场电位的自发γ波段（40-100Hz）功率升高。在本研究中，我们分析了在体诱导后背侧海马CA1（pdCA1）-PFC LTP/LTD前后的PFC局部场电位。与vCA1-PFC相反，本研究发现γ波段功率升高与pdCA1-PFC LTP相关，而与LTD无关，尽管我们观察到LTD与γ波段功率变化之间存在相关性。vCA1-和pdCA1-PFC通路之间的差异可能与突触可塑性和行为功能的差异有关。由于海马体和PFC的神经连接被认为参与工作记忆功能，PFC中持续的γ波段功率升高可能与此功能有关。
