Ma Li-Jun, Fogo Agnes B
MCN C3310, Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Semin Immunopathol. 2007 Nov;29(4):385-95. doi: 10.1007/s00281-007-0087-y. Epub 2007 Sep 8.
Regardless of the initial injury, the long-term consequence for the patient depends upon the ensuing balance of profibrotic vs reparative modulators activated. The glomerulus has some capacity for repair. Even when sclerosis has developed with accumulation of extracellular matrix, this lesion may be remodeled, with a change in balance between profibrotic and antifibrotic and collagen synthesis vs proteolytic mediators. We will focus here on the interplay between mediators of fibrosis and reparative mechanisms and potential regression of fibrosis. Based on the clinical efficacy of interventions that inhibit angiotensin, we will focus on factors related to the renin-angiotensin system.
无论初始损伤如何，患者的长期后果取决于随后激活的促纤维化与修复调节因子之间的平衡。肾小球具有一定的修复能力。即使在细胞外基质积累导致硬化形成时，这种病变也可能会重塑，促纤维化与抗纤维化以及胶原蛋白合成与蛋白水解介质之间的平衡会发生变化。我们将在此重点关注纤维化介质与修复机制之间的相互作用以及纤维化的潜在消退。基于抑制血管紧张素的干预措施的临床疗效，我们将重点关注与肾素-血管紧张素系统相关的因素。
