Yang X Y
Peking Union Medical College Hospital, Beijing.
Zhonghua Zhong Liu Za Zhi. 1991 Sep;13(5):346-9.
We report the results of our immunohistochemical study on the distribution and the retention time of the injected labelled antibodies in both primary and recurrent ovarian epithelial carcinomas and the regional lymph nodes, following the radioimmunodetection with injection of 131I-labelled polyclonal antibodies (including 5 cases of intravenous injection group and 35 cases of subcutaneous injection group). Six other tumors or tumor-like lesions, 8 normal ovaries and 7 normal fallopian tubes were used for control. The results demonstrated: 1. The labelled antibodies were specific for ovarian epithelial carcinoma, 2. The concentration of the labelled antibodies in the lymph node metastasis was higher in the subcutaneous injection group than in the intravenous injection group. Therefore, the subcutaneous route should be used both for imaging and radioimmunotherapy of lymph node metastasis, 3. The retention time of the antibodies in the lymph node metastasis was not more than 24 days. With this reference, the total dose of radioimmunotherapy can be calculated.
我们报告了在注射131I标记的多克隆抗体进行放射免疫检测后（包括5例静脉注射组和35例皮下注射组），对原发性和复发性卵巢上皮癌及区域淋巴结中注射的标记抗体的分布和保留时间进行免疫组织化学研究的结果。另外使用6个其他肿瘤或肿瘤样病变、8个正常卵巢和7个正常输卵管作为对照。结果表明：1. 标记抗体对卵巢上皮癌具有特异性；2. 皮下注射组淋巴结转移中标记抗体的浓度高于静脉注射组。因此，对于淋巴结转移的成像和放射免疫治疗均应采用皮下途径；3. 抗体在淋巴结转移中的保留时间不超过24天。以此为参考，可以计算放射免疫治疗的总剂量。
