Chen Shih-Jen, Liu Jorn-Hon, Shih Hui-Chuan, Chou Pesus, Tsai Ching-Yao, Tung Tao-Hsin
Community Medicine Research Center and Institute of Public Health, National Yang-Ming University, Taipei, Taiwan.
Acta Diabetol. 2008 Mar;45(1):7-13. doi: 10.1007/s00592-007-0012-9. Epub 2007 Sep 9.
The aim of this study is to assess the prevalence and associated risk factors of lens opacities among type 2 diabetics in Kinmen, Taiwan. A community-based mass screening ascertained 971 type 2 diabetics from 1991 to 1993. From that population, a total of 578 (59.5%) patients with type 2 diabetes underwent eye screening in 1999 with a 45 degrees thin slit-lamp biomicroscopy and ophthalmoscopy to examine the lens after dilation of the pupils. The prevalence of nuclear, cortical, and posterior subcapsular (PSC) opacity without surgery among type 2 diabetics was 22.5, 20.2, and 19.9%, respectively. The number of females affected was statistically higher than males in each type of lens opacity. The prevalence of each type of lens opacity also showed a statistically significant increase with (chi2 test). Based on multiple logistic regressions, age was the most significant factor related with each type of lens opacity. Triglyceride at baseline was associated with nuclear opacity (> or =200 vs. <200 mg/dl, OR = 2.35, 95% CI: 1.15-4.79) and PSC opacity (> or =200 vs. <200 mg/dl, OR = 2.11, 95% CI: 1.00-4.43). In conclusion, our results show that in addition to age, higher triglyceride level may increase the risk of prevalent nuclear or PSC opacity in type 2 diabetics.
本研究旨在评估台湾金门地区2型糖尿病患者晶状体混浊的患病率及相关危险因素。1991年至1993年，通过社区大规模筛查确定了971例2型糖尿病患者。在这些患者中，共有578例（59.5%）2型糖尿病患者于1999年接受了眼部筛查，采用45度薄裂隙灯生物显微镜检查和检眼镜检查，在瞳孔散大后检查晶状体。2型糖尿病患者中未经手术的核性、皮质性和后囊下（PSC）混浊的患病率分别为22.5%、20.2%和19.9%。在每种类型的晶状体混浊中，受影响的女性人数在统计学上高于男性。每种类型晶状体混浊的患病率也显示出统计学上的显著增加（卡方检验）。基于多因素logistic回归分析，年龄是与每种类型晶状体混浊相关的最显著因素。基线时的甘油三酯与核性混浊（≥200 vs.＜200mg/dl，OR = 2.35，95%CI：1.15 - 4.79）和PSC混浊（≥200 vs.＜200mg/dl，OR = 2.11，95%CI：1.00 - 4.43）相关。总之，我们的结果表明，除年龄外，较高的甘油三酯水平可能会增加2型糖尿病患者发生核性或PSC混浊的风险。
