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β-葡萄糖醛酸酶(β-GCD)检测在恶性肿瘤诊断中的临床应用——743例分析

[Clinical application of beta-glucuronidase (beta-GCD) assay in the diagnosis of malignant tumors--analysis of 743 cases].

作者信息

Wang W Z

机构信息

Liaoning Cancer Institute, Shenyang.

出版信息

Zhonghua Zhong Liu Za Zhi. 1991 Sep;13(5):359-61.

PMID:1782849
Abstract

Chromatometric assay of beta-GCD in the urine, gastric juice and saliva was conducted in 743 subjects. In the urine of 104 normal persons, 5 (4.8%) were beta-GCD positive. In the urine of 35 urinary bladder cancer patients, 20 (57.1%) were positive. beta-GCD content was very low in the gastric juice and saliva of normal subjects, giving a positivity of 0%. But it was high in the gastric juice of stomach cancer patients, giving a positive rate of 83.3%. The positivities in the saliva of stomach cancer and malignant ovarian tumor patients were both 62.2% which was higher than that of patients suffering from other malignancies or benign tumors. beta-GCD assay is simple, stable and is valid in the diagnosis of stomach cancer and ovarian malignancies. The mechanism of beta-GCD elevation and its relation to metastasis are discussed.

摘要

对743名受试者的尿液、胃液和唾液进行了β - 葡萄糖醛酸苷酶(beta - GCD)的色谱分析。在104名正常人的尿液中,5人(4.8%)β - GCD呈阳性。在35名膀胱癌患者的尿液中,20人(57.1%)呈阳性。正常受试者的胃液和唾液中β - GCD含量非常低,阳性率为0%。但在胃癌患者的胃液中含量较高,阳性率为83.3%。胃癌和恶性卵巢肿瘤患者唾液中的阳性率均为62.2%,高于其他恶性肿瘤或良性肿瘤患者。β - GCD检测简单、稳定,对胃癌和卵巢恶性肿瘤的诊断有效。本文讨论了β - GCD升高的机制及其与转移的关系。

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Zhonghua Zhong Liu Za Zhi. 1991 Sep;13(5):359-61.
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