Sun Peng, Han Jiyuan, Weng Yuying
Emergency Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
J Huazhong Univ Sci Technolog Med Sci. 2007 Aug;27(4):419-21. doi: 10.1007/s11596-007-0417-2.
To investigate the therapeutic effect of high-dosage gamma-aminobutyric acid (GABA) on acute tetramine (TET) poisoning, 50 Kunming mice were divided into 5 groups at random and the antidotal effects of GABA or sodium dimercaptopropane sulfonate (Na-DMPS) on poisoned mice in different groups were observed in order to compare the therapeutic effects of high-dosage GABA with those of Na-DMPS. Slices of brain tissue of the poisoned mice were made to examine pathological changes of cells. The survival analysis was employed. Our results showed that both high-dosage GABA and Na-DMPS could obviously prolong the survival time, delay onset of convulsion and muscular twitch, and ameliorate the symptoms after acute tetramine poisoning in the mice. Better effects could be achieved with earlier use of high dosage GABA or Na-DMPS. There was no significant difference in prolonging the survival time between high-dose GABA and Na-DMPS used immediately after poisioning. It is concluded that high-dosage GABA can effectively antagonize acute toxicity of teramine in mice. And it is suggested that high-dosage GABA may be used as an excellent antidote for acute TET poisoning in clinical practice. The indications and correct dosage for clinical use awaits to be further studied.
为研究高剂量γ-氨基丁酸（GABA）对急性毒鼠强（TET）中毒的治疗效果，将50只昆明小鼠随机分为5组，观察GABA或二巯丙磺酸钠（Na-DMPS）对不同组中毒小鼠的解毒作用，以比较高剂量GABA与Na-DMPS的治疗效果。制作中毒小鼠的脑组织切片，检查细胞的病理变化。采用生存分析。结果显示，高剂量GABA和Na-DMPS均可明显延长小鼠急性毒鼠强中毒后的存活时间，延迟惊厥和肌肉抽搐的发作，并改善症状。早期使用高剂量GABA或Na-DMPS效果更佳。中毒后立即使用高剂量GABA和Na-DMPS在延长存活时间方面无显著差异。结论：高剂量GABA可有效拮抗小鼠毒鼠强的急性毒性。建议高剂量GABA在临床实践中可作为急性TET中毒的优良解毒剂。其临床应用指征和正确剂量有待进一步研究。
