Wang Q L
Cancer Hospital, Chinese Academy of Medical Sciences, Beijing.
Zhonghua Zhong Liu Za Zhi. 1991 Sep;13(5):385-8.
From 1961 through 1986, 95 cases of Hodgkin's disease were biopsied in our hospital. Sex distribution: male 70, female 25. Age incidence: 27% were under 20 years and 75% under 40. 93% of lesions had originated from the lymph nodes. Clinical stage: I 14, II 37, III 25 and IV 19 cases. 20 patients were treated by chemotherapy, 26 by radiotherapy and 49 by combined chemotherapy and radiotherapy. The CR + PR rate was 86.2% and the 1-, 3-, 5- and 10-year survival rates were 83.2% (79/95), 57.6% (53/92), 46.4% (32/69) and 31.3% (15/48), respectively. The results showed that the 4 pathological types (LP, NS, MC, LD) and 10 subtypes (D,N in LP; LP, MC, LD in NS; LP, MC, LD in MC; R, DF in LD) and the predominance of reticulum cells (S-R cells, HD cells, histiocytes, lymphocytes, fibrosis, collagenous changes) in the tumor were all irrelevant to the prognosis (P greater than 0.05). However, the clinical stage, immediate response and the method of treatment were very prognostic (P less than 0.05) The authors believe that intensive chemotherapy combined with radiotherapy and intensive radiotherapy could lead to long survival.
1961年至1986年期间，我院对95例霍奇金病患者进行了活检。性别分布：男性70例，女性25例。年龄发病率：20岁以下者占27%，40岁以下者占75%。93%的病变起源于淋巴结。临床分期：Ⅰ期14例，Ⅱ期37例，Ⅲ期25例，Ⅳ期19例。20例患者接受化疗，26例接受放疗，49例接受化疗联合放疗。完全缓解（CR）+部分缓解（PR）率为86.2%，1年、3年、5年和10年生存率分别为83.2%（79/95）、57.6%（53/92）、46.4%（32/69）和31.3%（15/48）。结果显示，4种病理类型（淋巴细胞为主型、结节硬化型、混合细胞型、淋巴细胞消减型）和10个亚型（淋巴细胞为主型中的弥漫性、结节性；结节硬化型中的淋巴细胞为主型、混合细胞型、淋巴细胞消减型；混合细胞型中的淋巴细胞为主型、混合细胞型、淋巴细胞消减型；淋巴细胞消减型中的网状细胞型、弥漫性纤维化型）以及肿瘤中网状细胞（S-R细胞、霍奇金细胞、组织细胞、淋巴细胞、纤维化、胶原化改变）的优势均与预后无关（P>0.05）。然而，临床分期、近期疗效及治疗方法对预后有显著影响（P<0.05）。作者认为，强化化疗联合放疗以及强化放疗可使患者长期存活。
