Björkholm M, Holm G, Mellstedt H, Johansson B, Askergren J, Söderberg G
Scand J Haematol. 1977 Nov;19(5):487-95.
An unselected material of 83 consecutive and previously untreated adult patients with Hodgkin's disease (HD) from the Stockholm area is presented. The distribution of patients according to age was characteristically bimodal. The histopathological subtypes were 16% lymphocyte predominance (LP), 33% nodular sclerosis (NS), 37% mixed cellularity (MC) and 11% lymphocyte depletion (LD). The patients were treated with aggressive megavoltage irradiation and multidrug chemotherapy. Major factors affecting prognosis were age, clinical stage and constitutional symptoms. Patients with LP and NS subtypes had only slightly better prognosis that patients classified as MC and LD. The overall survival was 68% at 41/2 years, which is close to that reported from other groups with similar composition of their materials with regard to age, histopathology and stage.
本文呈现了来自斯德哥尔摩地区的83例未经选择、连续且此前未接受过治疗的成年霍奇金淋巴瘤（HD）患者的资料。患者年龄分布呈典型的双峰模式。组织病理学亚型为16%淋巴细胞为主型（LP）、33%结节硬化型（NS）、37%混合细胞型（MC）和11%淋巴细胞消减型（LD）。患者接受了积极的大剂量放疗和多药化疗。影响预后的主要因素为年龄、临床分期和全身症状。LP和NS亚型患者的预后仅略优于MC和LD亚型患者。4.5年时的总生存率为68%，这与其他年龄、组织病理学和分期构成相似的组所报告的生存率相近。
