Michaelidis Theologos M, Lie D Chichung
GSF-National Research Center for Environment and Health, Institute of Developmental Genetics, Ingolstädter Landstrasse 1, 85764, Munich-Neuherberg, Germany.
Cell Tissue Res. 2008 Jan;331(1):193-210. doi: 10.1007/s00441-007-0476-5. Epub 2007 Sep 9.
Wnt proteins have now been identified as major physiological regulators of multiple aspects of stem cell biology, from self-renewal and pluripotency to precursor cell competence and terminal differentiation. Neural stem cells are the cellular building blocks of the developing nervous system and provide the basis for continued neurogenesis in the adult mammalian central nervous system. Here, we outline the most recent advances in the field about the critical factors and regulatory networks involved in Wnt signaling and discuss recent findings on how this increasingly intricate pathway contributes to the shaping of the developing and adult nervous system on the level of the neural stem cell.
Wnt蛋白现已被确定为干细胞生物学多个方面的主要生理调节因子，从自我更新和多能性到前体细胞能力和终末分化。神经干细胞是发育中神经系统的细胞组成部分，并为成年哺乳动物中枢神经系统中持续的神经发生提供基础。在这里，我们概述了该领域中有关Wnt信号传导所涉及的关键因子和调控网络的最新进展，并讨论了关于这一日益复杂的信号通路如何在神经干细胞水平上对发育中和成年神经系统的形成产生影响的最新研究发现。
