Kubo Fumi, Nakagawa Shinichi
RIKEN Frontier Research System, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Dev Growth Differ. 2008 May;50(4):245-51. doi: 10.1111/j.1440-169X.2008.01033.x.
In the vertebrate retina, stem cells with prolonged proliferative capacities reside in the most peripheral region, the ciliary marginal zone (CMZ), and they persist even after the functional eye has formed. These stem cells contribute to the formation of the retinal structures during the postnatal period in vivo, or can expand as neurospheres in vitro. Despite the wealth of anatomical descriptions of the characteristics of CMZ cells, molecular mechanisms for their specification or maintenance have long been uncharacterized. Recent studies provide evidence that certain secreted signaling molecules act as key regulators at multiple steps during these processes. In this review, we discuss the molecular basis for the regulation of retinal stem cells and their related cell types, especially focusing on the role of Wnt signaling.
在脊椎动物视网膜中，具有长期增殖能力的干细胞位于最外周区域，即睫状边缘区（CMZ），即使在功能性眼睛形成后它们仍持续存在。这些干细胞在出生后体内对视网膜结构的形成有贡献，或者在体外可作为神经球扩增。尽管对CMZ细胞特征有丰富的解剖学描述，但其特化或维持的分子机制长期以来一直未被阐明。最近的研究提供了证据，表明某些分泌的信号分子在这些过程的多个步骤中起关键调节作用。在本综述中，我们讨论视网膜干细胞及其相关细胞类型调控的分子基础，尤其着重于Wnt信号的作用。
