Joyce Peter R, Light Katrina J, Rowe Sarah L, Kennedy Martin A
University of Otago Christchurch, Christchurch, New Zealand.
Aust N Z J Psychiatry. 2007 Oct;41(10):843-9. doi: 10.1080/00048670701579058.
To compare the personality, clinical and comorbidity characteristics of subjects meeting diagnostic criteria for bipolar disorder not otherwise specified (BDNOS) to those with major depression and bipolar I or II disorder.
A family-based study was undertaken on the molecular genetics of depression and personality, in which the proband had been treated for depression, regardless of history, of hypomania or mania.
The 25 subjects with BDNOS were different to the 297 subjects with major depression and similar to 75 subjects with bipolar I or II disorder on social phobia, obsessive-compulsive disorder and substance dependence comorbidity. The BDNOS subjects also had personality traits more akin to the bipolar I or II disorder subjects, especially borderline personality traits and self transcendence.
Subjects with BDNOS, based on a history of 1-3 day recurrent hypomanias, should be included within a broader bipolar spectrum.
比较未特定型双相情感障碍（BDNOS）符合诊断标准的受试者与重度抑郁症、双相I型或II型障碍受试者的人格、临床和共病特征。
针对抑郁症和人格的分子遗传学开展了一项基于家系的研究，其中先证者无论有无轻躁狂或躁狂病史均接受过抑郁症治疗。
25例BDNOS受试者在社交恐惧症、强迫症和物质依赖共病方面与297例重度抑郁症受试者不同，而与75例双相I型或II型障碍受试者相似。BDNOS受试者的人格特质也更类似于双相I型或II型障碍受试者，尤其是边缘型人格特质和自我超越。
基于1 - 3天复发性轻躁狂病史的BDNOS受试者应纳入更广泛的双相谱系中。
