Radziewicz Henry, Uebelhoer Luke, Bengsch Bertram, Grakoui Arash
Emory University School of Medicine, 954 Gatewood Road, NE, Atlanta, GA 30329, United States.
World J Gastroenterol. 2007 Sep 28;13(36):4848-57. doi: 10.3748/wjg.v13.i36.4848.
Chronic viral infections such as hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are major global health problems affecting more than 500 million people worldwide. Virus-specific CD8+ T cells play an important role in the course and outcome of these viral infections and it is hypothesized that altered or impaired differentiation of virus-specific CD8+ T cells contributes to the development of persistence and/or disease progression. A deeper understanding of the mechanisms responsible for functional differentiation of CD8+ T cells is essential for the generation of successful therapies aiming to strengthen the adaptive component of the immune system.
慢性病毒感染，如乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）和人类免疫缺陷病毒（HIV），是影响全球超过5亿人的主要全球健康问题。病毒特异性CD8 + T细胞在这些病毒感染的病程和结果中发挥着重要作用，据推测，病毒特异性CD8 + T细胞分化的改变或受损会导致持续性感染和/或疾病进展。深入了解负责CD8 + T细胞功能分化的机制，对于开发旨在增强免疫系统适应性成分的成功疗法至关重要。
