Department of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Institute for Immunology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Immunol Rev. 2018 May;283(1):232-237. doi: 10.1111/imr.12642.
Memory CD8 T cells are essential in orchestrating protection from re-infection. Hallmarks of virus-specific memory CD8 T cells are the capacity to mount recall responses with rapid induction of effector cell function and antigen-independent survival. Growing evidence reveals that even chronic infection does not preclude virus-specific CD8 T-cell memory formation. However, whether this kind of CD8 T-cell memory that is established during chronic infection is indeed functional and provides protection from re-infection is still unclear. Human chronic hepatitis C virus infection represents a unique model system to study virus-specific CD8 T-cell memory formation during and after cessation of persisting antigen stimulation.
记忆性 CD8 T 细胞对于协调防止再次感染至关重要。病毒特异性记忆性 CD8 T 细胞的特征是具有快速诱导效应细胞功能和抗原非依赖性存活的能力，从而引发回忆反应。越来越多的证据表明，即使是慢性感染也不会排除病毒特异性 CD8 T 细胞记忆的形成。然而，在慢性感染期间建立的这种 CD8 T 细胞记忆是否确实具有功能并提供免受再感染的保护仍然不清楚。人类慢性丙型肝炎病毒感染代表了一个独特的模型系统，可用于研究持续抗原刺激停止后病毒特异性 CD8 T 细胞记忆的形成。
