Garcia J H, Kalimo H, Givens J R
Arch Pathol Lab Med. 1976 May;100(5):253-8.
The manifestations that comprise the disease known as Nelson syndrome are pituitary hyperplasia and cutaneous hyperpigmentation, which sometimes follow bilateral adrenalectomy, in patients with hypercortisolism. We present a comprehensive endocrinologic, structural study of a patient in whom the evidence obtained supports the hypotheses that: (a) the primary disorder in this form of hypercortisolism is probably hypothalamic; (b) the hyperplasia of the adenohypophysis, following adrenalectomy, is closely associated with lowered plasma cortisol levels; and (c) the cillular hyperplasia in the adenohypophysis involves primarily the corticotroph, a cell believed to be associated with the secretion of adrenocorticotrophic hormone and melanocyte-stimulating hormone.
被称为尼尔森综合征的疾病表现包括垂体增生和皮肤色素沉着，有时发生在皮质醇增多症患者双侧肾上腺切除术后。我们对一名患者进行了全面的内分泌学和结构研究，所获得的证据支持以下假设：(a) 这种形式的皮质醇增多症的原发性疾病可能是下丘脑性的；(b) 肾上腺切除术后腺垂体增生与血浆皮质醇水平降低密切相关；(c) 腺垂体的细胞增生主要涉及促肾上腺皮质激素细胞，该细胞被认为与促肾上腺皮质激素和促黑素细胞激素的分泌有关。
