Romeo J M, Lopez-Farre A, Martin-Paredero V, Lopez-Novoa J M
Department of Surgery, Fundación Jimenez Diaz-CSIC, Madrid, Spain.
Eur Surg Res. 1991;23(3-4):195-200. doi: 10.1159/000129152.
The purpose of this study was to determine the renal function derangements that portacaval shunting caused in previously normal rats. Eight rats suffered a surgical portacaval shunt (PCS) and another 8 a sham operation (SHAM). Renal function was investigated by determining urinary volume, sodium, potassium, creatinine and aldosterone excretion, in basal conditions and after sodium overload. Plasma renin concentration and urinary excretion of PGE2, 6-keto-PGF1 alpha and TXB2 were also determined in basal conditions. PCS rats showed increased urinary volume, creatinine excretion and endogenous creatinine clearance, either in basal conditions or after sodium load. After the latter, PCS animals also showed sodium retention and hyperaldosteronuria. PCS caused in basal conditions a striking diminution in urinary excretion of all prostaglandins and no changes in plasma renin. In conclusion, PCS in the normal rat caused a renal dysfunction consisting of polyuria, possibly related to ADH disfunction and an inability to manage a sodium load.
本研究的目的是确定门腔分流对先前正常大鼠肾功能的影响。8只大鼠接受了门腔分流手术（PCS），另外8只进行了假手术（SHAM）。通过测定基础状态和钠负荷后尿体积、钠、钾、肌酐和醛固酮排泄来研究肾功能。还在基础状态下测定了血浆肾素浓度以及PGE2、6-酮-PGF1α和TXB2的尿排泄量。PCS大鼠在基础状态或钠负荷后，尿体积、肌酐排泄和内生肌酐清除率均增加。在钠负荷后，PCS动物还表现出钠潴留和醛固酮尿增多。PCS在基础状态下导致所有前列腺素的尿排泄显著减少，而血浆肾素无变化。总之，正常大鼠的PCS导致肾功能障碍，表现为多尿，可能与抗利尿激素功能障碍以及无法处理钠负荷有关。
