Escape from genomic imprinting at the mouse T-associated maternal effect (Tme) locus.
作者信息
Tsai J Y, Silver L M
机构信息
Department of Molecular Biology, Princeton University, New Jersey 08544-1014.
出版信息
Genetics. 1991 Dec;129(4):1159-66. doi: 10.1093/genetics/129.4.1159.
Abstract
Genomic imprinting occurs at the paternally inherited allele of the mouse T-associated maternal effect (Tme) locus. As a consequence, maternal transmission of a functional Tme gene is normally required for viability and individuals that receive a Tme-deleted chromosome (Thp or tlub2) from their mother die late in gestation or shortly thereafter. Here we report that a rearranged paternally derived chromosome duplicated for the Tme locus can act to rescue animals that have not received a maternal copy of the Tme locus. Unexpectedly, all rescued animals display an abnormal short/kinky tail phenotype. Somatic transfer of genomic imprinting between homologs by means of a transvection-like process between paired Tme and T loci is proposed as a model to explain the results obtained.
摘要
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