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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Mills C F, Dalgarno A C, Wenham G

Br J Nutr. 1976 May;35(3):309-31. doi: 10.1079/bjn19760039.

Copper deficiency was induced in five Friesian cattle offered a semi-synthetic diet containing less than 1 mgCu/kg. Changes in blood and liver Cu contents and in the Cu-containing enzymes, ferroxidase I (caeruloplasmin; EC 1.16.3.1) and monoamine oxidase (EC 1.4.3.4) of plasma and cytochrome oxidase (EC 1.9.3.1) of liver and skeletal muscle were monitored during Cu depletion. 2. Rapid decreases in blood and liver Cu and plasma ferroxidase I activity were found at least 80 d before the first appearance of overt clinical signs of deficiency. Plasma monoamine oxidase and liver cytochrome oxidase activities decreased less rapidly and thus may provide useful indices of chronic Cu depletion.

给五头弗里斯兰奶牛投喂含铜量低于1毫克/千克的半合成日粮，诱导其出现铜缺乏症。在铜缺乏期间，监测血液和肝脏中的铜含量，以及血浆中的含铜酶亚铁氧化酶I（血浆铜蓝蛋白；EC 1.16.3.1）和单胺氧化酶（EC 1.4.3.4），还有肝脏和骨骼肌中的细胞色素氧化酶（EC 1.9.3.1）的变化。2. 在首次出现明显的铜缺乏临床症状前至少80天，就发现血液和肝脏中的铜以及血浆亚铁氧化酶I活性迅速下降。血浆单胺氧化酶和肝脏细胞色素氧化酶活性下降速度较慢，因此可能是慢性铜缺乏的有用指标。

Mills C F, Dalgarno A C, Wenham G

Br J Nutr. 1976 May;35(3):309-31. doi: 10.1079/bjn19760039.

Copper deficiency was induced in five Friesian cattle offered a semi-synthetic diet containing less than 1 mgCu/kg. Changes in blood and liver Cu contents and in the Cu-containing enzymes, ferroxidase I (caeruloplasmin; EC 1.16.3.1) and monoamine oxidase (EC 1.4.3.4) of plasma and cytochrome oxidase (EC 1.9.3.1) of liver and skeletal muscle were monitored during Cu depletion. 2. Rapid decreases in blood and liver Cu and plasma ferroxidase I activity were found at least 80 d before the first appearance of overt clinical signs of deficiency. Plasma monoamine oxidase and liver cytochrome oxidase activities decreased less rapidly and thus may provide useful indices of chronic Cu depletion.

给五头弗里斯兰奶牛投喂含铜量低于1毫克/千克的半合成日粮，诱导其出现铜缺乏症。在铜缺乏期间，监测血液和肝脏中的铜含量，以及血浆中的含铜酶亚铁氧化酶I（血浆铜蓝蛋白；EC 1.16.3.1）和单胺氧化酶（EC 1.4.3.4），还有肝脏和骨骼肌中的细胞色素氧化酶（EC 1.9.3.1）的变化。2. 在首次出现明显的铜缺乏临床症状前至少80天，就发现血液和肝脏中的铜以及血浆亚铁氧化酶I活性迅速下降。血浆单胺氧化酶和肝脏细胞色素氧化酶活性下降速度较慢，因此可能是慢性铜缺乏的有用指标。