Reed A M, Pachman L, Ober C
Division of Immunology/Rheumatology, Children's Memorial Hospital, Northwestern University Medical School, Chicago, Illinois.
Hum Immunol. 1991 Dec;32(4):235-40. doi: 10.1016/0198-8859(91)90085-n.
Juvenile dermatomyositis (JDMS) is an inflammatory disease associated with HLA-DR3. We therefore undertook molecular genetic studies of HLA region genes to determine whether HLA-DR3 itself confers susceptibility to JDMS or whether susceptibility is conferred by alleles in linkage disequilibrium with HLA-DR3. Our results indicate that JDMS is associated with the HLA-DQA1 allele DQA1 *0501 on non-DR3 haplotypes in Caucasian JDMS. Furthermore, the reported of association between the C4A gene deletion and JDMS is likely due to linkage disequilibrium with HLA-DR3.
青少年皮肌炎（JDMS）是一种与HLA - DR3相关的炎症性疾病。因此，我们对HLA区域基因进行了分子遗传学研究，以确定HLA - DR3本身是否赋予对JDMS的易感性，或者易感性是否由与HLA - DR3处于连锁不平衡状态的等位基因赋予。我们的结果表明，在白种人JDMS患者的非DR3单倍型上，JDMS与HLA - DQA1等位基因DQA1 * 0501相关。此外，报道的C4A基因缺失与JDMS之间的关联可能是由于与HLA - DR3的连锁不平衡。
