多个种族群体中HLA - DQA1*0501等位基因与青少年皮肌炎的关联。

Association of the HLA-DQA1*0501 allele in multiple racial groups with juvenile dermatomyositis.

作者信息

Reed A M, Stirling J D

机构信息

Department of Pediatrics, University of North Carolina at Chapel Hill, USA.

出版信息

Hum Immunol. 1995 Nov;44(3):131-5. doi: 10.1016/0198-8859(95)00035-6.

DOI:10.1016/0198-8859(95)00035-6

PMID:8666549

Abstract

We wanted to determine if HLA-DQA10501 is as strongly associated with JDMS in Hispanic and African Americans as it is Caucasians. Using DNA sequencing and oligonucleotide typing, the DNA of 70 JDMS subjects was studied. The HLA-DQA1 allelle DQA10501 was present in 13 out of 15 (87%) of the African-American JDMS subjects vs 9 out of 27 (33%) of the African-American controls (p < 0.0009), 12 out of 13 (92%) of the Hispanic JDMS subjects vs 5 out of 18 (28%) of the Hispanic controls (p < 0.0004), and 36 out of 42 (86%) of the Caucasian JDMS subjects vs 36 out of 78 (46%) of the Caucasian controls (p < 0.0009).

摘要

我们想确定HLA - DQA10501在西班牙裔和非裔美国人中与青少年皮肌炎（JDMS）的关联是否与在白种人中一样紧密。我们使用DNA测序和寡核苷酸分型技术，对70名青少年皮肌炎患者的DNA进行了研究。在15名非裔美国青少年皮肌炎患者中，有13名（87%）存在HLA - DQA1等位基因DQA10501，而非裔美国对照组的27名中有9名（33%）存在该等位基因（p < 0.0009）；在13名西班牙裔青少年皮肌炎患者中，有12名（92%）存在该等位基因，而西班牙裔对照组的18名中有5名（28%）存在该等位基因（p < 0.0004）；在42名白种人青少年皮肌炎患者中，有36名（86%）存在该等位基因，而白种人对照组的78名中有36名（46%）存在该等位基因（p < 0.0009）。