Cochrane E, McCarthy I D
Department of Orthopaedic Surgery, University of Edinburgh, Medical School.
J Endocrinol. 1991 Dec;131(3):359-65. doi: 10.1677/joe.0.1310359.
The vascular effects of noradrenaline, ATP, parathyroid hormone (PTH) and prostaglandin E2 (PGE2) were investigated in the rat. Additionally, the exchange of mineral ions between bone and blood was assessed by measuring strontium clearance, with the aim of investigating whether the vascular effects of these agents altered uptake of mineral ions or if this exchange could be changed independently of blood flow. Radioactive microspheres and 85Sr were used to establish bone blood flow and mineral clearance. Measurements of bone blood flow and arterial pressure were made in each animal and used to calculate vascular resistance. A measurement of 85Sr clearance was also obtained. Arterial blood pressure was significantly affected by noradrenaline (P less than or equal to 0.003) and ATP (P less than or equal to 0.015). Additionally, noradrenaline significantly (P less than or equal to 0.03) reduced bone blood flow. This decrease was related to a significant increase in vascular resistance. Arterial blood pressure and bone blood flow were significantly reduced by both bovine PTH(1-34) (P less than or equal to 0.001, P less than or equal to 0.02) and PGE2 (P less than or equal to 0.005, P less than or equal to 0.001). Vascular resistance to bone was increased by both agents but this was only statistically significant in the case of PGE2 (P less than or equal to 0.01). A significant (P less than or equal to 0.001) reduction in strontium was also produced by PGE2. In each group the relationship between bone blood flow and strontium clearance was then analysed.(ABSTRACT TRUNCATED AT 250 WORDS)
在大鼠体内研究了去甲肾上腺素、三磷酸腺苷（ATP）、甲状旁腺激素（PTH）和前列腺素E2（PGE2）对血管的影响。此外，通过测量锶清除率来评估骨与血液之间矿物质离子的交换，目的是研究这些药物的血管作用是否会改变矿物质离子的摄取，或者这种交换是否可以独立于血流而发生变化。使用放射性微球和85锶来确定骨血流量和矿物质清除率。在每只动物身上测量骨血流量和动脉血压，并用于计算血管阻力。还获得了85锶清除率的测量值。去甲肾上腺素（P≤0.003）和ATP（P≤0.015）对动脉血压有显著影响。此外，去甲肾上腺素显著（P≤0.03）降低了骨血流量。这种减少与血管阻力的显著增加有关。牛甲状旁腺激素（1-34）（P≤0.001，P≤0.02）和PGE2（P≤0.005，P≤0.001）均显著降低了动脉血压和骨血流量。两种药物都增加了对骨的血管阻力，但只有PGE2的情况在统计学上有显著意义（P≤0.01）。PGE2还导致锶显著（P≤0.001）减少。然后分析了每组中骨血流量与锶清除率之间的关系。（摘要截短于250字）
