Thorat S, Dahanukar S
Department of Pharmacology, Seth G. S. Medical College, Bombay, Maharashtra.
J Postgrad Med. 1991 Jul;37(3):157-9.
Crude aconite is an extremely lethal substance. However, the science of Ayurveda looks upon aconite as a therapeutic entity. Crude aconite is always processed i.e. it undergoes 'samskaras' before being utilised in the Ayurvedic formulations. This study was undertaken in mice, to ascertain whether 'processed' aconite is less toxic as compared to the crude or unprocessed one. It was seen that crude aconite was significantly toxic to mice (100% mortality at a dose of 2.6 mg/mouse) whereas the fully processed aconite was absolutely non-toxic (no mortality at a dose even 8 times as high as that of crude aconite). Further, all the steps in the processing were essential for complete detoxification.
生草乌是一种极具致命性的物质。然而,阿育吠陀医学将草乌视为一种治疗药物。生草乌总是经过炮制的,即在用于阿育吠陀配方之前要经过“净化处理”。本研究在小鼠身上进行,以确定“炮制后的”草乌与未加工的生草乌相比毒性是否更低。结果发现,生草乌对小鼠具有显著毒性(剂量为2.6毫克/只小鼠时死亡率为100%),而完全炮制后的草乌则完全无毒(即使剂量高达生草乌的8倍也无死亡)。此外,炮制过程中的所有步骤对于完全解毒都是必不可少的。