Li H, Xiong S T, Zhang S X, Luo Y, Feng Z H
Department of Surgery, Xiehe Hospital, Tongji Medical University, Wuhan.
J Tongji Med Univ. 1991;11(3):150-4. doi: 10.1007/BF02888126.
In this study we used an experimental model produced by bile duct ligation (BDL) in rats to demonstrate relation between immune function and susceptibility to infection associated with obstructive jaundice and immunoregulatory effect of arginine in BDL rats. Our experimental results showed that thymus weight, content of lymphocytes in thymus and responsiveness to Con A in vitro were dramatically reduced in BDL rats as compared to rats with sham operation and that the impairment of lymphocyte function was significantly related to the susceptibility to infection. Arginine, as a T cell stimulator, markedly improved immune function and decreased susceptibility to infection of BDL rats.
在本研究中，我们采用大鼠胆管结扎（BDL）制备的实验模型，以证明免疫功能与梗阻性黄疸相关感染易感性之间的关系，以及精氨酸对BDL大鼠的免疫调节作用。我们的实验结果表明，与假手术大鼠相比，BDL大鼠的胸腺重量、胸腺中淋巴细胞含量及体外对刀豆蛋白A的反应性显著降低，且淋巴细胞功能的损害与感染易感性显著相关。精氨酸作为一种T细胞刺激剂，可显著改善BDL大鼠的免疫功能并降低其感染易感性。
