Cacabelos R, Barquero M, García P, Alvarez X A, Varela de Seijas E
Laboratory of Psychobiology and Behavioral Sciences, Complutense University Medical School, Madrid, Spain.
Methods Find Exp Clin Pharmacol. 1991 Sep;13(7):455-8.
Recent studies indicate that patients with Alzheimer's disease (AD) exhibit an immune dysfunction at the central and peripheral levels. We have studied the concentration of IL-1 beta in the cerebrospinal fluid (CSF) of patients with AD, multi-infarct dementia (MID), normal pressure hydrocephalus (NPH), and multiple sclerosis (MS). CSF IL-1 beta levels were significantly higher in AD (131 +/- 17.33 pg/ml) than in MID (79.71 +/- 24.37 pg/ml, p less than 0.01), NPH (84.75 +/- 23.17 pg/ml, p less than 0.01), and MS (79.4 +/- 10.23 pg/ml, p less than 0.01). In patients with neurological disorders CSF IL-1 beta levels showed a progressive increase with age (r = +0.49, p less than 0.015). The concentration of IL-1 beta in CSF of demented patients correlated with mental deterioration (r = -0.476). According to these results we postulate that high levels of central IL-1 beta in AD might reflect a reactive neuroimmune response to: (a) abnormal epitopes exposed by lesioned neurons, (b) reactive microglia activated by exogenous and/or endogenous factors and (c) endogenous neurotrophic activation.
近期研究表明，阿尔茨海默病（AD）患者在中枢和外周水平均表现出免疫功能障碍。我们研究了AD、多发梗死性痴呆（MID）、正常压力脑积水（NPH）和多发性硬化症（MS）患者脑脊液（CSF）中IL-1β的浓度。AD患者的脑脊液IL-1β水平（131±17.33 pg/ml）显著高于MID患者（79.71±24.37 pg/ml，p<0.01）、NPH患者（84.75±23.17 pg/ml，p<0.01）和MS患者（79.4±10.23 pg/ml，p<0.01）。在患有神经系统疾病的患者中，脑脊液IL-1β水平随年龄呈渐进性升高（r = +0.49，p<0.015）。痴呆患者脑脊液中IL-1β的浓度与精神衰退相关（r = -0.476）。根据这些结果，我们推测AD患者中枢IL-1β水平升高可能反映了对以下情况的反应性神经免疫反应：（a）受损神经元暴露的异常表位，（b）由外源性和/或内源性因素激活的反应性小胶质细胞，以及（c）内源性神经营养激活。
