Neyens Ron, Jackson Kenneth C
University of Florida Shands Jacksonville Medical Center, Department of Pharmacy, Jacksonville, FL, USA.
J Pain Palliat Care Pharmacother. 2007;21(2):27-33.
Methylnaltrexone and alvimopan are two new and potentially useful agents in the management of opioid-induced bowel dysfunction and prevention of postoperative ileus. Both agents have promising prokinetic properties and appear to be capable of reversing the effects of opioids on delayed gastrointestinal transit. This article reviews currently available published literature to provide an overview of the clinical trials and to provide insight for the potential use of these agents for patients requiring opioid based analgesia. These compounds represent a new class of compounds that may impact the therapeutics for opioid induced bowel dysfunction as well as postoperative ileus.
甲基纳曲酮和阿维莫潘是治疗阿片类药物引起的肠功能障碍和预防术后肠梗阻的两种新型且可能有用的药物。这两种药物都具有有前景的促动力特性，似乎能够逆转阿片类药物对胃肠道转运延迟的影响。本文回顾了目前已发表的文献，以概述临床试验情况，并为这些药物在需要阿片类镇痛的患者中的潜在应用提供见解。这些化合物代表了一类新型化合物，可能会影响阿片类药物引起的肠功能障碍以及术后肠梗阻的治疗方法。
