Chayasirisobhon Wuttichai V, Chayasirisobhon Sirichai, Tin Sue Nwe, Leu Ngoc, Tehrani Keo, McGuckin Jeanne S
Department of Neurology, Kaiser Permanente Medical Center, Anaheim, California 92807, USA.
Clin EEG Neurosci. 2007 Jul;38(3):168-71. doi: 10.1177/155005940703800314.
We studied scalp-recorded auditory event-related potentials (ERPs) of 30 untreated patients with new-onset temporal lobe epilepsy and 30 age- and sex-matched normal controls. This study was designed to eliminate the effects of intractability of seizures and chronic use of antiepileptic drugs on P300 auditory ERPs. There were no statistically significant differences in both latency and amplitude of P300 between the two groups. Similar methods were also used to analyze component latencies and amplitudes of ERPs of 9 patients who had hippocampal sclerosis with comparison to control subjects. There were no statistically significant differences between these two groups as well. Our study evidently does not support temporal lobe sources of P300 scalp-recorded auditory ERPs. We also conclude that the scalp-recorded auditory ERPs procedure is not a useful tool to evaluate temporal lobe epilepsy.
我们研究了30例新发性颞叶癫痫未经治疗的患者以及30例年龄和性别匹配的正常对照者头皮记录的听觉事件相关电位（ERP）。本研究旨在消除癫痫难治性和长期使用抗癫痫药物对P300听觉ERP的影响。两组之间P300的潜伏期和波幅均无统计学显著差异。我们还采用类似方法分析了9例海马硬化患者与对照者ERP各成分的潜伏期和波幅。这两组之间也无统计学显著差异。我们的研究显然不支持P300头皮记录听觉ERP的颞叶来源。我们还得出结论，头皮记录听觉ERP检查并非评估颞叶癫痫的有用工具。
