Rocha Caroline Nunes, Miziara Carmen Silvia Molleis Galego, Manreza Maria Luiza Giraldes de, Schochat Eliane
University of São Paulo School of Medicine Rua Cipotanea 51, Cidade Universitária 05360-000 São Paulo SP, Brasil.
Arq Neuropsiquiatr. 2010 Feb;68(1):18-24. doi: 10.1590/s0004-282x2010000100005.
The purpose of this study was to determine the repercussions of left temporal lobe epilepsy (TLE) for subjects with left mesial temporal sclerosis (LMTS) in relation to the behavioral test-Dichotic Digits Test (DDT), event-related potential (P300), and to compare the two temporal lobes in terms of P300 latency and amplitude. We studied 12 subjects with LMTS and 12 control subjects without LMTS. Relationships between P300 latency and P300 amplitude at sites C3A1,C3A2,C4A1, and C4A2, together with DDT results, were studied in inter-and intra-group analyses. On the DDT, subjects with LMTS performed poorly in comparison to controls. This difference was statistically significant for both ears. The P300 was absent in 6 individuals with LMTS. Regarding P300 latency and amplitude, as a group, LMTS subjects presented trend toward greater P300 latency and lower P300 amplitude at all positions in relation to controls, difference being statistically significant for C3A1 and C4A2. However, it was not possible to determine laterality effect of P300 between affected and unaffected hemispheres.
本研究的目的是确定左侧颞叶癫痫（TLE）对患有左侧颞叶内侧硬化（LMTS）的受试者在行为测试——双耳分听数字测试（DDT）、事件相关电位（P300）方面的影响，并比较两个颞叶在P300潜伏期和波幅方面的差异。我们研究了12名患有LMTS的受试者和12名未患有LMTS的对照受试者。在组间和组内分析中，研究了C3A1、C3A2、C4A1和C4A2部位的P300潜伏期和P300波幅之间的关系，以及DDT结果。在DDT测试中，与对照组相比，患有LMTS的受试者表现较差。双耳的这种差异均具有统计学意义。6名患有LMTS的个体未引出P300。关于P300潜伏期和波幅，作为一个整体，与对照组相比，LMTS受试者在所有位置均呈现出P300潜伏期延长和P300波幅降低的趋势，C3A1和C4A2部位的差异具有统计学意义。然而，无法确定受影响半球和未受影响半球之间P300的偏侧化效应。
