副肿瘤性边缘叶脑炎中的复杂部分性癫痫持续状态

Complex partial status epilepticus in paraneoplastic limbic encephalitis.

作者信息

Kile S J, Kim J C, Seyal M

机构信息

Department of Neurology, University of California-Davis Medical Center, California, USA.

出版信息

Clin EEG Neurosci. 2007 Jul;38(3):172-4. doi: 10.1177/155005940703800315.

DOI:10.1177/155005940703800315

PMID:17844948

Abstract

Paraneoplastic limbic encephalitis (PLE) results from tumor-related autoimmune mediated inflammation and degeneration of the mesial temporal structures. Cognitive and behavioral changes and seizures occur in PLE. Seizures are an uncommon presenting symptom of PLE occurring in 6 of 50 patients in one series. We present a report of complex partial status epilepticus (CPSE) as the presentation of PLE with anti-neuronal antibodies and improvement in mental status following treatment of seizures.

摘要

副肿瘤性边缘叶脑炎（PLE）是由肿瘤相关的自身免疫介导的中颞叶结构炎症和变性引起的。PLE会出现认知和行为改变以及癫痫发作。癫痫发作是PLE不常见的首发症状，在一组50例患者中有6例出现。我们报告一例以复杂部分性癫痫持续状态（CPSE）为表现的PLE病例，该患者存在抗神经元抗体，癫痫发作治疗后精神状态有所改善。