Nissen Mette, Blaabjerg Morten
Ugeskr Laeger. 2017 Jul 24;179(30).
Autoimmune encephalitis is characterized by formation of antibodies against cell surface proteins. Antibodies against the gamma-aminobuturic acidB (GABAB) receptor lead to limbic encephalitis, drug-resistant seizures, confusion, cognitive impairment and changed behaviour. Some patients present with status epilepticus. GABAB encephalitis is associated with small-cell lung cancer or neuroendocrine lung tumour. This is a case report of a patient having status epilepticus due to GABAB encephalitis. In cases which are presumed to be autoimmune it is important that treatment starts immediately instead of awaiting antibody confirmation.
自身免疫性脑炎的特征是针对细胞表面蛋白形成抗体。抗γ-氨基丁酸B（GABAB）受体抗体可导致边缘叶脑炎、耐药性癫痫发作、意识模糊、认知障碍和行为改变。一些患者会出现癫痫持续状态。GABAB脑炎与小细胞肺癌或神经内分泌性肺肿瘤有关。这是一例因GABAB脑炎导致癫痫持续状态的病例报告。在疑似自身免疫性的病例中，重要的是立即开始治疗，而不是等待抗体确认。
