Herbert Z, Bötticher G, Aschoff A, Sendemir E, Zermann D-H, Arnold R, Mall G, Jirikowski G F
Department of Biology II, Institute of Neurobiology, LMU, München, Germany.
Anat Histol Embryol. 2007 Oct;36(5):361-5. doi: 10.1111/j.1439-0264.2007.00775.x.
Several observations suggest that caveolin-1 has an important role in control of cell proliferation and cancerogenesis. For instance, oxytocin provokes a proliferative response in the prostate tissue when the oxytocin receptor is localized mainly in caveolin-1-enriched domains and an anti-proliferative effect when the same receptor is not localized in caveolae. Moreover, oxytocin concentrations are elevated in prostate tissue of patients with benign prostatic hyperplasia (BPH). In this study the expression pattern of the molecules caveolin-1, oxytocin receptor, androgen receptor and p21 (cell cycle arrest indicator) was investigated in the prostate tissue of BPH patients and of young controls. We found that both caveolin-1 and oxytocin receptor expression is drastically increased with age in both smooth muscle and epithelium of the prostate. We also found a significantly increased co-localization of the oxytocin receptor with caveolin-1 in both the muscle and the epithelium, especially in BPH patients. Androgen receptor and p21 staining was found throughout the prostate but did not change significantly with age or in BPH patients. We conclude that oxytocin may have a proliferative effect on the prostate tissue through the caveolae-associated receptors and thus contribute to BPH. This process seems to be androgen receptor independent.
多项观察结果表明，小窝蛋白-1在控制细胞增殖和癌症发生过程中发挥着重要作用。例如，当催产素受体主要定位于富含小窝蛋白-1的结构域时，催产素会在前列腺组织中引发增殖反应；而当同一受体不在小窝中定位时，则会产生抗增殖作用。此外，良性前列腺增生（BPH）患者的前列腺组织中催产素浓度会升高。在本研究中，我们调查了BPH患者和年轻对照者前列腺组织中分子小窝蛋白-1、催产素受体、雄激素受体和p21（细胞周期停滞指标）的表达模式。我们发现，随着年龄增长，前列腺平滑肌和上皮细胞中的小窝蛋白-1和催产素受体表达均显著增加。我们还发现，在肌肉和上皮细胞中，尤其是在BPH患者中，催产素受体与小窝蛋白-1的共定位显著增加。雄激素受体和p21染色在整个前列腺中均有发现，但随年龄增长或在BPH患者中无显著变化。我们得出结论，催产素可能通过与小窝相关的受体对前列腺组织产生增殖作用，从而导致BPH。这一过程似乎与雄激素受体无关。
