Consoli Angèle, Soultanian Charlotte, Tanguy Marie-Laure, Laurent Claudine, Perisse Didier, Luque Rogelio, Berrios German E, Cohen David
Department of Child and Adolescent Psychiatry, Comportement et Cognition, Université Pierre et Marie Curie, Assistance Publique, Hopitaux de Paris, Hôpital Pitié-Salpétrière, Paris, France.
Bipolar Disord. 2007 Sep;9(6):665-8. doi: 10.1111/j.1399-5618.2007.00420.x.
To assess the effect of age at onset on the phenomenology of Cotard's syndrome (CS) as a recent study reported a high rate of occurrence of bipolar disorder (BD) in adolescents and young adults with CS followed up for > or =2 years.
We reviewed all cases of CS reported since it was first described. A statistical analysis was carried out to determine the effect of age at onset on CS phenomenology.
We found 138 cases including 21 cases aged 25 years or younger. In these younger CS patients, BD was more frequent, and the risk of associated BD was increased nine times (p < 0.0001). Within the BD sub-group (n = 27), admixture analysis identified two sub-groups with mean ages at onset of 18.7 years [standard deviation (SD) = 3.2] and 50.5 years (SD = 11.7).
Young people with CS should be monitored carefully for the onset of BD, and families should be educated about this risk. Treatment with mood stabilizers can be helpful for those who develop BD. Within BD associated with CS, early versus late onset should be distinguished.
鉴于最近一项研究报告称，随访时间≥2年的患有科塔尔综合征（CS）的青少年和青年中双相情感障碍（BD）的发生率很高，评估发病年龄对科塔尔综合征（CS）现象学的影响。
我们回顾了自首次描述以来报告的所有CS病例。进行了统计分析以确定发病年龄对CS现象学的影响。
我们发现了138例病例，其中包括21例年龄在25岁及以下的病例。在这些较年轻的CS患者中，BD更为常见，且伴发BD的风险增加了9倍（p<0.0001）。在BD亚组（n = 27）中，混合分析确定了两个亚组，平均发病年龄分别为18.7岁[标准差（SD）= 3.2]和50.5岁（SD = 11.7）。
应密切监测患有CS的年轻人是否出现BD，并应向其家人介绍这种风险。对于那些发展为BD的患者，使用心境稳定剂进行治疗可能会有所帮助。在与CS相关的BD中，应区分早发和晚发。
