Tufft L S, Nockels C F
Department of Animal Sciences, Colorado State University, Ft. Collins 80523.
Poult Sci. 1991 Dec;70(12):2439-49. doi: 10.3382/ps.0702439.
The present study determined effects of Escherichia coli infection, crowding stress, and EDTA supplementation on Cu, Fe, and Zn levels in the serum, liver, bursa of Fabricius, and spleen of chickens. Organ weights as a percentage of BW were affected by treatments prior to and after infection. Liver and spleen weights as a percentage of BW increased with infection but bursa weight decreased. One week of stress increased hepatic Cu, but 3 wk of EDTA ingestion increased serum Cu and serum, hepatic, bursal, and splenic Fe. These elemental changes resulting from EDTA may have predisposed the chicks to a higher mortality rate from E. coli compared with controls. Peak mortality occurred 2 days after infection, coincident with an increased serum Cu, decreased serum and bursal Fe and Zn, and increased hepatic and splenic Zn. At 7 days postinfection, recovering chicks experienced decreased hepatic Fe, elevated hepatic Zn, decreased bursal Cu, Fe, and Zn, and increased splenic Cu, Fe, and Zn. The current study demonstrates the interactive effects of EDTA, stress, and E. coli infection on serum and organ trace element concentration.
本研究确定了大肠杆菌感染、饲养密度应激和补充乙二胺四乙酸（EDTA）对鸡血清、肝脏、法氏囊和脾脏中铜、铁和锌水平的影响。感染前后，各处理组的器官重量占体重的百分比均受到影响。感染后，肝脏和脾脏重量占体重的百分比增加，但法氏囊重量下降。一周的应激增加了肝脏中的铜含量，但连续3周摄入EDTA增加了血清铜以及血清、肝脏、法氏囊和脾脏中的铁含量。与对照组相比，EDTA导致的这些元素变化可能使雏鸡更容易因大肠杆菌感染而出现更高的死亡率。感染后2天出现死亡高峰，此时血清铜增加，血清、法氏囊中的铁和锌减少，肝脏和脾脏中的锌增加。感染后7天，正在恢复的雏鸡肝脏中铁含量降低，肝脏中锌含量升高，法氏囊中铜、铁和锌含量降低，脾脏中铜、铁和锌含量增加。本研究证明了EDTA、应激和大肠杆菌感染对血清和器官微量元素浓度的交互作用。
